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American Society of Microbiology ABMM Sample Questions (Q73-Q78):
NEW QUESTION # 73
Vancomycin resistance in Enterococcus faecium, mediated by the vanA gene cluster, results from:
- A. Enzymatic inactivation of vancomycin by phosphorylation
- B. Decreased outer membrane permeability to vancomycin
- C. Modification of the drug target from D-alanyl-D-alanine to D-alanyl-D-lactate
- D. Efflux pump overexpression removing vancomycin from the cell
Answer: C
NEW QUESTION # 74
During the investigation of a foodborne illness outbreak linked to raw sprouts, several bacterial isolates are obtained from patient stool samples and the implicated food source. Which of the following molecular methods would be MOST useful for establishing a definitive link between the clinical isolates and the food isolate?
- A. Gram staining and biochemical profiling
- B. Pulsed-field gel electrophoresis (PFGE)
- C. Antimicrobial susceptibility testing
- D. Serotyping based on O and H antigens
Answer: B
NEW QUESTION # 75
A research team is investigating the host immune response to Mycobacterium tuberculosis. They discover that a specific mycobacterial glycolipid inhibits the maturation of phagosomes containing the bacteria, preventing their fusion with lysosomes. This mechanism allows M. tuberculosis to:
- A. Escape from the phagolysosome into the cytoplasm.
- B. Induce the production of pro-inflammatory cytokines.
- C. Evade detection by Toll-like receptors on macrophages.
- D. Survive and replicate within macrophages.
Answer: D
NEW QUESTION # 76
A microbiology laboratory receives a cerebrospinal fluid (CSF) sample from a patient with suspected meningitis. Gram stain shows numerous Gram-negative diplococci. The organism grows on chocolate agar but not on blood agar without added CO2. The MOST likely identification is:
- A. Streptococcus pneumoniae
- B. Listeria monocytogenes
- C. Neisseria meningitidis
- D. Haemophilus influenzae
Answer: C
NEW QUESTION # 77
A clinical microbiology laboratory is implementing whole-genome sequencing (WGS) for enhanced surveillance of Listeria monocytogenes isolates associated with foodborne outbreaks. WGS provides several advantages over traditional subtyping methods like pulsed-field gel electrophoresis (PFGE). Which of the following is the MOST significant advantage of WGS in this context?
- A. Lower cost per isolate compared to PFGE.
- B. Higher discriminatory power for resolving phylogenetic relationships and identifying outbreakclusters.
- C. Easier standardization and inter-laboratory comparison of data.
- D. Faster turnaround time for obtaining results.
Answer: B
NEW QUESTION # 78
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